Stuart MacGowan

Publications

• Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
• Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants
• Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) α-solenoid domain
• Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies.
• The Dundee Resource for Sequence Analysis and Structure Prediction
• PDBe-KB: a community-driven resource for structural and functional annotations
• Contribution of bacteriochlorophyll conformation to the distribution of site-energies in the FMO protein.
• Conformational control of cofactors in nature - the influence of protein-induced macrocycle distortion on the biological function of tetrapyrroles.
• Expanding the clinical spectrum of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis due to FAM111B mutations.
• Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin.
• Computational quantification of the physicochemical effects of heme distortion: redox control in the reaction center cytochrome subunit of Blastochloris viridis.
• Conformational control of cofactors in nature--functional tetrapyrrole conformations in the photosynthetic reaction centers of purple bacteria.
• Chlorophylls, Symmetry, Chirality, and Photosynthesis
• ChemInform Abstract: Conformational Control of Cofactors in Nature - The Influence of Protein-Induced Macrocycle Distortion on the Biological Function of Tetrapyrroles
• 61 The Structural Chemistry of Isolated Chlorophylls
• Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues
• Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19
• Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
• Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics
• Ankyrin repeats in context with human population variation
• Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
• A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites
• Classification of likely functional state for ligand binding sites identified from fragment screening
• Classification of likely functional class for ligand binding sites identified from fragment screening
• A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites