Flat tissue culture flask mimics the mechanobiology environment of human tissue in providing a surface for cell attachment and growth

Cells in the human tissue and organ grow in a highly congested environment, where close contact and proximity to other cells is the norm. Hence, at the micro-level, cells in tissues grow on a flat surface, adjacent to or on-top of other cells. Cast a glance at the common flat tissue culture flask in mammalian cell culture, and it is clear that the flat bottom is mimicking the mechanobiology environment of the cellular microenvironment. Such an environment provides a surface for cell attachment and growth, and affords some resemblance to human tissue or organ environment in understanding the various phenotypic effects exhibited by mammalian cells in tissue culture flask. In short, development of flat tissue culture flask is a technological breakthrough that, for the first time, allows researchers to culture cells in a tissue-mimicry environment. Although two-dimensional in format, and lacking the three-dimensional sensory inputs of cells in real-tissue, the flat tissue culture flask still provide a good environment to obtain physiological readout of mammalian cells in artificial culture environment. In essence, the flat tissue culture flask allows us to culture and manipulate cells in an effort to understand their behaviour and physiology.