np8007396_si_001.pdf (3.61 MB)
Oleanane-Type Isomeric Triterpenoids from Barringtonia racemosa
journal contribution
posted on 2009-04-24, 00:00 authored by P. Mangala Gowri, S. V. S. Radhakrishnan, S. Jeelani Basha, A. V. S. Sarma, J. Madhusudana RaoTwo new isomeric acylated oleanane-type triterpenoids along with three known compounds were isolated from the MeOH extract of the dried fruits of Barringtonia racemosa. On the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques as well as chemical methods, the structures were characterized as racemosol A (1) [22α-acetoxy-3β,15α,16α,21β-tetrahydroxy-28-(2-methylbutyryl)olean-12-ene] and isoracemosol A (2) [21β-acetoxy-3β,15α,16α,28-tetrahydroxy-22α-(2-methylbutyryl)olean-12-ene]. The isolated compounds (1−5) were not active against HeLa and P388 D1 carcinoma cell lines.