ol9b02632_si_001.pdf (4.08 MB)
Cobalt-Catalyzed Ortho-C(sp2)–H Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Groups
journal contributionposted on 2019-09-02, 04:29 authored by Jie Huang, Jun Ding, Tong-Mei Ding, Shuiyi Zhang, Yaqiu Wang, Feng Sha, Shu-Yu Zhang, Xin-Yan Wu, Qiong Li
An efficient and convenient cobalt-catalyzed ortho-C(sp2)–H amidation of benzaldehydes employing dioxazolones as the aminating reagent has been developed. The key feature of this protocol is the use of green and economic earth-abundant metals cobalt as the catalyst with the p-chloroaniline as the transient directing group. Further application of our approach was demonstrated by the synthesis of C1r serine protease inhibitor 45 and elastase inhibitor 49.