2017-11-01T10:59:05Z (GMT) by Martin Hadley Philippa Matthews
<p>Hepitopes is a project to collate all the existing HBV epitopes restricted by HLA Class I genes, and to develop this into a live on-line resource that can grow and develop over time.</p><p>The initial stage of this work has been to perform a literature search to identify all epitopes that have been published to date. We have undertaken a detailed review of all the references such that we can list epitope HLA-restrictions, locations in the HBV proteome, sequences and polymorphisms, and report preliminary data regarding the potential clinical significance of epitope-specific T cell immune responses.</p><p>Over time, this database will continue to be updated such that we can develop and maintain an open-access resource that is useful for basic research and clinical vaccine design. This will include new epitopes identified as a result of my own work in Hepatitis B immunogenetics, as well as continuing to identify and collate new epitopes published by other groups.</p><a href="https://github.com/martinjhnhadley/hepitopes#data-and-license-details"></a>Data and License Details<table><tr><th></th><th></th></tr><tr><td>Data:</td><td><a href="https://dx.doi.org/10.6084/m9.figshare.4015824">https://dx.doi.org/10.6084/m9.figshare.4015824</a> (Live Data) <br><a href="https://dx.doi.org/10.5287/bodleian:zr0VAr78q">https://dx.doi.org/10.5287/bodleian:zr0VAr78q</a> (Deposit at time of publication)</td></tr><tr><td>Live Visualisation:</td><td><a href="http://www.expmedndm.ox.ac.uk/hepitopes">www.expmedndm.ox.ac.uk/hepitopes</a></td></tr><tr><td>Citing works:</td><td>Lumley S, Noble H, Hadley M et al. Hepitopes: literature review and database of HLA Class I epitopes in Hepatitis B Virus (HBV) [v1; not peer reviewed]. F1000Research 2016, 5:2357 (poster) (doi: <a href="http://dx.doi.org/10.7490/f1000research.1113165.1">10.7490/f1000research.1113165.1</a></td></tr><tr><td>License:</td><td>MIT</td></tr><tr><td>Copyright:</td><td>University of Oxford, 2016</td></tr><tr><td>Authors:</td><td>Lumley, Sheila <br><a href="http://orcid.org/0000-0001-5891-2932">Noble, Howard</a><br><a href="https://github.com/martinjhnhadley/hepitopes/blob/master/orcid.org/0000-0002-3039-6849">Hadley, Martin</a><br>Callow, Liz<br>Malik, Amna<br>Chua, Yi Yi<br>Duffey, Owen J<br>Grolmusova, Natalia<br>Kumar, Arvind<br>Ravenscroft, Samuel<br>Spencer, Jonathan I<br>Neumann-Haefelin, Christoph<br>Thimme, Robert<br>Andersson, Monique<br>Klenerman, Paul<br>Barnes, Eleanor<br><a href="http://orcid.org/0000-0002-4036-4269">Matthews, Philippa</a></td></tr></table>