tgcl_a_1528389_sm3853.docx (3.64 MB)
γ-aminobutyric acid and collagen peptides as recyclable bifunctional biocatalysts for the solvent-free one-pot synthesis of 2-aminobenzothiazolomethyl-2-naphthols
journal contribution
posted on 2018-10-08, 13:30 authored by Maryam Fardpour, Ali Safari, Shahrzad Javanshirγ-aminobutyric acid (GABA) and Isinglass a collagen peptide have been utilized as highly efficient bifunctional biocatalysts for the efficient and convenient synthesis of 2-aminobenzothiazolomethyl-2-naphthols through a one-pot three-component Mannich reaction between diverse aldehydes, 2-naphthol and 2-aminobenzothiazole under solvent-free condition in high yields. Moreover, GABA could be recycled and reused at least four times without noticeable loss of its activity.