The clinical significance of concomitant bacteriuria in patients with <i>Staphylococcus aureus</i> bacteremia. A review and meta-analysis

2018-09-03T06:48:29Z (GMT) by Stamatis Karakonstantis Dimitra Kalemaki
<p><b>Background:</b><i>Staphylococcus aureus</i> bacteriuria (SABU) concomitant to <i>S. aureus</i> bacteremia (SAB) has been associated with deep-seated infections and worse prognosis. However, the relevant studies were small and inconsistent. Here, we aim to provide a review of the relevant literature, and a meta-analysis of these studies.</p> <p><b>Methods:</b> We searched PubMed and Scopus for studies comparing patients with SAB and concomitant SABU to patients with SAB without SABU.</p> <p><b>Results:</b> Nine relevant studies were identified, involving 1429 patients with SAB, of whom 18.5% (<i>n</i> = 265) had concomitant SABU. Pooling the results of those studies, SABU was significantly associated with endocarditis, bone/joint infection and septic embolism. SABU was also associated with persistent SAB, and higher mortality.</p> <p><b>Conclusions:</b> Although SABU may be a useful marker of complicated SAB, the current literature has several limitations. Larger prospective studies are required to clarify the value of SABU in clinical decision making.</p>