ol9b02060_si_001.pdf (8.4 MB)
Tabernabovines A–C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina
journal contribution
posted on 2019-07-11, 00:00 authored by Yang Yu, Mei-Fen Bao, Jing Wu, Jing Chen, Yu-Rong Yang, Johann Schinnerl, Xiang-Hai CaiThree monoterpenoid
indole alkaloids (MIAs), tabernabovines A–C
(1–3), were isolated from Tabernaemontana bovina. They were elucidated by spectroscopic
data and computational calculations. Unlike precursors of MIAs, strictosidine
and alstrostine A, alkaloid 1 consists of tryptamine
and secologanin in a 2:1 ratio. Alkaloid 2 is a cage
compound, and 3 possesses a bridged ring. Tabernabovine
A exhibited inhibitory activity against NO production with IC50 44.1 μM compared to l-NMMA with IC50 of 48.6 μM.