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Synthesis and Degradation Study of Cationic Polycaprolactone-Based Nanoparticles for Biomedical and Industrial Applications
journal contribution
posted on 2017-05-05, 00:00 authored by Azzurra Agostini, Simone Gatti, Alberto Cesana, Davide MoscatelliPositively
charged polymers have increased in importance in the
last years because of the possibility of being used in many different
applications, from gene delivery to polymer flooding applications
and as flocculants in wastewater treatment. In all cases, the possibility
of obtaining biodegradable colloidal products leads to great advantages.
In this work, positively charged nanoparticles (NPs) have been produced
via free radical emulsion polymerization (FREP). This synthetic route
was selected since it is widely used in industry and it facilitates
large scale production along with control of some key features of
the final NPs such as their size, surface charge, and particle size
distribution dispersity. NP synthesis was carried out by a four-step
process: the synthesis of biodegradable ester-based macromonomers
obtained through the ring-opening polymerization of the ε-caprolactone,
the reaction among the obtained macromonomer and succinic anhydride,
the final condensation with choline chloride to obtain the positively
charged macromonomer, and the FREP polymerization of the produced
macromonomer. The effects of reaction conditions on NP characteristics
were studied, and the tunable behavior of the obtained charged NPs
has been proven, also in terms of degradation time.
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Keywords
gene deliveryreaction conditionsFREP polymerizationsuccinic anhydridetunable behaviorIndustrial Applications Positivelyapplicationemulsion polymerizationcholine chloridering-opening polymerizationester-based macromonomersDegradation StudyNP synthesisfour-step processscale productionparticle size distribution dispersitysurface chargeε- caprolactoneNP characteristicsdegradation timeCationic Polycaprolactone-Based Nanoparticleswastewater treatment
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