ol8b01778_si_001.pdf (2.63 MB)
Stereocontrolled Synthesis of Triols Containing Four Asymmetric Centers: Application of C,O‑Chelated Germyl Enolates to a Diastereoselective Aldol Reaction
journal contribution
posted on 2018-06-22, 20:47 authored by Yohei Minami, Akihito Konishi, Makoto YasudaThe treatment of α,β-unsaturated
ketones with divalent
germanium salts cleanly generated C,O-chelated germyl enolates. The aldol reactions of the chelated enolates
with the aldehydes achieved a high diastereoselectivity in the construction
of the five-membered aldol adducts. Furthermore, the subsequent transformation
of the Ge–C bond in the aldol adduct enabled the stereocontrolled
synthesis of triols bearing four asymmetric centers.