ganp_a_1484455_sm3270.pdf (6.53 MB)
Six new diterpenoids from Croton laevigatus
journal contribution
posted on 2018-08-21, 12:29 authored by Mo-Nan Liu, Meng-Meng Zhang, Jing-Ya Li, Jia Li, Yao-Yue Fan, Jian-Min YueSix new ent-labdane-type diterpeniods (1‒6), along with one known compound, were identified from the twigs and leaves of Croton laevigatus. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 2 and 7 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 4.11 and 8.33 μg/ml, respectively.