Rhodium-Catalyzed Asymmetric Cyclization/Addition
Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes

Zhou, Yongyun; Yu, Lu; Chen, Jingchao; Xu, Jianbin; He, Zhenxiu; Shen, Guoli; Fan, Baomin

doi:10.1021/acs.orglett.7b04044.s001

ol7b04044_si_001.pdf (3.67 MB)

Rhodium-Catalyzed Asymmetric Cyclization/Addition Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes

journal contribution

posted on 2018-02-12, 05:33 authored by Yongyun Zhou, Lu Yu, Jingchao Chen, Jianbin Xu, Zhenxiu He, Guoli Shen, Baomin Fan

A mild, efficient, and novel rhodium catalyzed asymmetric cyclization–addition domino reaction of oxa/azabenzonorbornadienes and 1,6-enynes is documented. Through the use of a [Rh(COD)₂]BF₄-(R)-An-SDP catalytic system, highly enantioenriched cyclization–addition products were obtained in good yields and with excellent enantioselectivities.