PharmacotherapyDB 1.0: the open catalog of drug therapies for disease

This is the initial release of the PharmacotherapyDB, a catalog of drug therapies for disease. The catalog contains physician curated medical indications.<div><br></div><div>This release contains 97 diseases and 601 drugs. Between these drug–disease pairs, there are 755 disease-modifying therapies, 390 symptomatic therapies, and 243 non-indications. To enable integrative analyses, drugs and diseases are coded using <a href="http://www.drugbank.ca/">DrugBank</a> and <a href="http://disease-ontology.org/">Disease Ontology</a> identifiers.</div><div><br></div><div><p>Indications were classified by physician curators into three categories:</p><ul><li><code>DM</code> -- disease modifying</li><li><code>SYM</code> -- symptomatic</li><li><code>NOT</code> -- non-indication</li></ul></div><div><br></div><div>This deposition contains the following files:</div><div><ul><li><p><a href="https://github.com/dhimmel/indications/blob/11d535ba0884ee56c3cd5756fdfb4985f313bd80/catalog/indications.tsv"><code>indications.tsv</code></a> contains drug–disease pairs and their consensus category (<code>DM</code>, <code>SYM</code>, or <code>NOT</code>). <code>n_curators</code> refers to how many of the three curators initially assigned the consensus classification. <code>n_resources</code> refers to how many of the four resources (MEDI-HPS, LabeledIn, EHRLink, PREDICT) included the indication.</p></li><li><p><a href="https://github.com/dhimmel/indications/blob/11d535ba0884ee56c3cd5756fdfb4985f313bd80/catalog/diseases.tsv"><code>diseases.tsv</code></a> contains a list of diseases with indications. For each disease, the number of indications per category is provided.</p></li><li><p><a href="https://github.com/dhimmel/indications/blob/11d535ba0884ee56c3cd5756fdfb4985f313bd80/catalog/drugs.tsv"><code>drugs.tsv</code></a> contains a list of drugs with indications. For each drug, the number of indications per category is provided.</p></li><li><p><a href="https://github.com/dhimmel/indications/blob/11d535ba0884ee56c3cd5756fdfb4985f313bd80/catalog/catalog.xlsx"><code>catalog.xlsx</code></a> is a spreadsheet with four sheets:</p></li><ol><li><code>indications</code> — data from <code>indications.tsv</code></li><li><code>diseases</code> — data from <code>diseases.tsv</code></li><li><code>drugs</code> — data from <code>drugs.tsv</code></li><li><code>curation</code> — the classifications from each of the three physician curators (<code>AJG</code>, <code>CSH</code>, & <code>PK</code>).</li></ol></ul><div>The catalog is released as CC0 1.0. However, please consider that the catalog includes DrugBank and DIsease Ontology identifiers and reference their licenses when appropriate.</div></div>