Palladium-Catalyzed Multicomponent Reaction of Alkynes,
Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative
Olefins

Gao, Mingchun; Zou, Minfen; Wang, Jue; Tan, Qitao; Liu, Bingxin; Xu, Bin

doi:10.1021/acs.orglett.9b00137.s001

ol9b00137_si_001.pdf (3.57 MB)

Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins

journal contribution

posted on 2019-02-25, 20:49 authored by Mingchun Gao, Minfen Zou, Jue Wang, Qitao Tan, Bingxin Liu, Bin Xu

A palladium-catalyzed multicomponent reaction of alkynes, carboxylic acids, and isocyanides has been developed with the assistance of silver salt under mild conditions. Highly functionalized captodative olefins are synthesized efficiently by this method, which can find many applications as versatile synthons in organic synthesis.

Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins

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