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Mesoporous Organosilica Nanoparticles Containing Superacid and Click Functionalities Leading to Cooperativity in Biocidal Coatings
journal contribution
posted on 2015-01-14, 00:00 authored by Julia Gehring, David Schleheck, Bastian Trepka, Sebastian PolarzA superior degree of functionality
in materials can be expected, if two or more operational entities
are related in a cooperative form. It is obvious that, for this purpose,
one is seeking materials with complex design comprising bi- or multiple
functional groups complementing each other. In the current paper,
it is demonstrated that periodically ordered mesoporous organosilicas
(PMOs) based on co-condensation of sol–gel precursors with
bridging phenyl derivatives RF1,2C6H3[Si(OisoPr)3]2 allow for rich opportunities
in providing high-surface area materials with such a special chemical
architecture. PMOs containing high density of thiol (≅ RF1) and sulfonic acid units (≅ RF2) were
prepared as mesoporous nanoparticles via an aerosol-assisted gas-phase
method and were tested for biocidal applications. Each of the mentioned
organic groups fulfills several tasks at once. The selective functionalization
of thiols located at the surface of the particles using click chemistry
leads to durable grafting on different substrates like glass or stainless
steel, and the intraparticle −SH groups are important regarding
the uptake of metal ions like Ag+ and for immobilization
of Ag0 nanoparticles inside the pores as an enduring reservoir
for antibacterial force. The superacidic sulfonic acid groups exhibit
a strong and instantaneous biocidal acitivity, and they are important
for adjusting the Ag+ release rate. Biological studies
involving inhibitory investigation tests (MIC), fluorescence microscopy
(life/dead staining), and bacterial adhesion tests with Pseudomonas
aeruginosa show that the organobifunctional materials present
much better performance against biofilm formation compared to materials
containing only one of the above-mentioned groups.
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Biocidal CoatingsARFbiocidal applicationsmetal ionssuperacidic sulfonic acid groups exhibitadhesion testsMesoporous Organosilica Nanoparticles Containing SuperacidMICgroups complementingmesoporous organosilicasrelease rateAg 0 nanoparticlesbiofilm formationbiocidal acitivityClick FunctionalitiesBiological studiesPseudomonas aeruginosa showPMOthiolinvestigation testsSHmesoporous nanoparticlesorganobifunctional materialsclick chemistrychemical architecture
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