np7b00121_si_001.pdf (3.65 MB)
Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge
journal contribution
posted on 2017-04-28, 11:49 authored by Chang-Kwon Kim, Riswanto Riswanto, Tae Hyung Won, Heegyu Kim, Berna Elya, Chung J. Sim, Dong-Chan Oh, Ki-Bong Oh, Jongheon ShinFive new manzamine alkaloids (1–5) and new salt forms of two known manzamines
(6 and 7), along with seven known compounds
(8–14) of the same structural class,
were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis of the results of combined spectroscopic
analyses, the structure of kepulauamine A (1) was determined
to possess an unprecedented pyrrolizine moiety, while others were
functional group variants of known manzamines. These compounds exhibited
weak cytotoxicity, moderate antibacterial activity, and mild inhibition
against the enzyme isocitrate lyase.