jo302815m_si_001.pdf (2.21 MB)
Enantioselective Synthesis of 4,5-Dihydropyrroles via Domino Ring-Opening Cyclization (DROC) of N‑Activated Aziridines with Malononitrile
journal contribution
posted on 2013-03-15, 00:00 authored by Manas K. Ghorai, Deo Prakash TiwariAn efficient and practical strategy
for the synthesis of highly
functionalized racemic and non-racemic 4,5-dihydropyrroles via domino
ring-opening cyclization (DROC) of activated aziridines with malononitrile
in excellent yield and stereoselectivity is described. The reaction
serves as a tool for the synthesis of a large variety of substituted
4,5-dihydropyrroles in enantiomerically pure forms.