Design and Applications of N-tert-Butyl Sulfinyl Squaramide Catalysts

Li, Yao; He, Cyndi Qixin; Gao, Fei-Xiang; Li, Zhen; Xue, Xiao-Song; Li, Xin; Houk, K. N.; Cheng, Jin-Pei

doi:10.1021/acs.orglett.7b00727.s001

ol7b00727_si_001.pdf (6.37 MB)

Design and Applications of N-tert-Butyl Sulfinyl Squaramide Catalysts

journal contribution

posted on 2017-03-29, 21:49 authored by Yao Li, Cyndi Qixin He, Fei-Xiang Gao, Zhen Li, Xiao-Song Xue, Xin Li, K. N. Houk, Jin-Pei Cheng

A new chiral HBD system, N-tert-butyl sulfinyl squaramide, was designed and synthesized. The core N-tert-butyl sulfinyl squaramide with an 1-aminoindan-2-ol skeleton was found to be an efficient catalyst in the enantioselective Friedel–Crafts alkylation of indoles and acyl phosphonates.