ol7b02316_si_001.pdf (5.46 MB)
Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)–H and C(sp3)–H Bonds
journal contribution
posted on 2017-08-22, 20:20 authored by Qun Li, Weipeng Hu, Renjian Hu, Hongjian Lu, Guigen LiCatalytic oxidative
cross-dehydrogenative coupling between unactivated
C(sp2)–H and C(sp3)–H bonds is
achieved by the cobalt-catalyzed o-alkylation reaction
of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine
(PIP–NH2) as a N,N-bidentate directing group. Many different C(sp3)–H
bonds in alkanes, toluene derivatives and even in the α-position
of ethers and thioethers can be used as coupling partners. This method
has a broad substrate scope and the tolerance of various functional
groups.