posted on 2007-05-30, 00:00authored byYousuke Yamaoka, Hideto Miyabe, Yoshiji Takemoto
A newly designed thiourea catalyst provides sufficient activation of organoboronic acids to facilitate the enantioselective Petasis transformation of quinolines even at low temperatures. A high degree of stereocontrol was achieved in the reaction of various quinolines and organoboronic acids by using a combination of H2O and NaHCO3 as additives.