lsyc_a_1473442_sm6548.docx (1.71 MB)
A convenient method for the synthesis of fluorinated α-cyanoacetates via phase-transfer catalysis
journal contribution
posted on 2018-06-28, 20:04 authored by Kavita Jain, Kalpataru DasA simple and convenient method for the synthesis of fluorinated α-cyanoacetate derivatives has been developed by using electrophilic fluorination of allyl and benzyl substituted α-cyanoacetates with N-fluorobenzensulfonimide (NFSI) as electrophilic fluorinating agent via phase transfer catalysis. The reaction is transition metal free and carried out in aqueous and mild reaction conditions in the presence of readily available tetra-N-butylammonium iodide (TBAI) as phase-transfer catalyst.