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Data Source Files of A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
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dataset
modified on 2019-04-18, 13:00 we
postulate that the structures of the bacterial signals can be mimicked by using non-toxic biomolecules of
simple design. Based on bioactivity screening, we devise a glucomannan
polysaccharide with acetyl modification at a degree of 1.8 (acGM-1.8), which specifically activates
toll-like receptor 2 (TLR2) signaling and
consequently induces macrophages into an anti-tumor
phenotype.