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Data Source Files of A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

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modified on 2019-04-18, 13:00
we postulate that the structures of the bacterial signals can be mimicked by using non-toxic biomolecules of simple design. Based on bioactivity screening, we devise a glucomannan polysaccharide with acetyl modification at a degree of 1.8 (acGM-1.8), which specifically activates toll-like receptor 2 (TLR2) signaling and consequently induces macrophages into an anti-tumor phenotype.

Funding

Science and Technology Development Fund, Macao SAR (FDCT 080/2016/A2 and 126/2016/A3)

the University of Macau Research Committee (MYRG2016-00031-ICMS-QRCM and MYRG2017-00028-ICMS)