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Fig 2 B.xlsx; Fig 2D.xlsx; Fig 3E.xlsx; Fig 7.xlsx; Fig 5D
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dataset
modified on 2019-12-11, 17:28 This dataset are for the manuscript that was submitted to Nature Biomedical Engineering which was transferred to Communications Biology and is considered for review.
The dataset collected are for Figure 2B, Figure 2D, Figure 3E, Figure 5D and Figure 7.
Figure 2B relates to volume of stent remaining following in-vitro degradation of LZ61-KBMS stent in bioreactor calculated based on the 3D structure of AZ31 and LZ61-KBMS stents (n=3).
Figure 2D relates to the presence and elemental percentages of O, Mg, Ca and P present in the degradation layer deposited on the stents after 5 weeks of immersion as measured by EDAX. (n=3, *P<0.05).
Figure 3E relates to tracheal lumen area calculations following in-vivo implantation of LZ61-KBMS stents in healthy rabbit tracheal model. The tracheal lumen area was calculated based on the cross-section of optical coherence tomography (OCT) images collected at 4, 8 and 12 weeks. **denotes a significant difference between alloy groups (p <0.01, n=3).
Figure 5D relates to Alcian blue staining of stented rabbit trachea tissue and shows the number of goblet cells counted per 1 mm along the epithelium. The data shows no statistical difference identified among the different groups counted (P > 0.05).
Figure 7 is a summary of the corrosion rate of LZ61-KBMS and AZ31 alloy under different tests.
Immersion test: 5-week corrosion rates calculated based on the immersion test; Electrochemical test: corrosion rates
calculated based on Tafel plot; 4 weeks subcutaneous implantation: corrosion rates calculated based on the
weight loss after 4 weeks of implantation; 12 weeks subcutaneous implantation: corrosion rates calculated
based on the weight loss after 12 weeks of implantation; Bioreactor: corrosion rate calculated based on the
stent volume loss after 5 weeks of immersion in bioreactor; Rabbit trachea implantation: corrosion rate
calculated based on the stent volume loss after 4 weeks implantation in rabbit trachea. *denotes a significant
difference between alloy groups (p <0.05, n=3). Corrosion rates calculated from bioreactor and rabbit trachea
implantation are from current study, the rest are derived from our previous study (Reference 31 in the main manuscript and given below).
Reference 31: Wu, J. et al. In Vitro and in Vivo Evaluation of Multiphase Ultrahigh Ductility Mg–Li–Zn Alloys for Cardiovascular Stent Application. ACS Biomaterials Science & Engineering 4, 919‐932, doi:10.1021/acsbiomaterials.7b00854 (2018).
