Figure 3

Figure. 3. Ovariectomy decreases amyloid pathology in App^NL-G-F-VAChT^over females, and the effect is blocked by estradiol. (B) Immunoblots of VAChT expression in the cortex of OVX App^NL-G-F and App^NL-G-F-VAChT^over females at 2 months and 3 months of age compared to sham-operated controls. Synaptophysin (syn) was used as loading control. (H) Immunoblot of VAChT expression in the cortex of estradiol-treated OVX App^NL-G-F and App^NL-G-F-VAChT^over females at 2 months of age compared to placebo-treated controls. Synaptophysin (syn) was used as loading control.