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Data from a systematic literature review to determine the relationship between HBsAg (prevalence of HBV infection) and anti-HBc (exposure to HBV infection) in African populations.

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modified on 12.03.2020, 09:11
This file set contains the metadata for an analysis of HBV sero-epidemiology data for Africa. We set out to investigate the relationship between prevalence of hepatitis B virus (HBV) infection and prevalence of exposure to infection.

We used HBsAg as a marker of active infection and anti-HBc as a marker of HBV exposure (including active infection, and exposed/cleared infection).

We gathered data from a literature review of PubMed and Web of Science searching for either “HBV antibody”, “antiHBc”, “HB core antibody”, “HBV exposure” or, “HBV prevalence” AND “Africa” or [Name of specific country]. Only papers published after the introduction of universal HBV vaccination in Africa in 1995 were included. Identified articles were reviewed to ensure both HBsAg and corresponding HBcAb prevalence for a given population were included.

Ethics permission was not required for this study,

Meta-data table: Data extracted from studies identified in a systematic literature search for studies including anti-HBc and HBsAg prevalence data for African countries published between 1995-2019. A total of 96 studies spanning 39 African countries were identified in the search, generating 109 unique data points representing independent cohorts. A PMID or DOI is provided for each manuscript. When a PMID or DOI could not be found (n=2), ISI or ISSN was provided. A key and notes on the table is given at the foot of the table.

Quality assessment table: formal assessment of the 96 studies included in the meta-analysis. Studies were assessed using established guidelines from the Johanna Briggs Institute for the critical appraisal of the scientific literature (1). Complete metadata for the manuscript are available in Table 1. All studies included in this analysis assessed the prevalence of HBsAg and anti-HBc. The sample size required for each was different. Sample size was assessed using guidelines established by Naing et al, (2006) (2). Notes on the studies are given at the foot of the table.


1. Munn Z, MClinSc SM, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. International Journal of Evidence-Based Healthcare. 2015;13(3):147–53.

2. Naing L, Winn T, Rusli BN. Practical Issues in Calculating the Sample Size for Prevalence Studies. Archives of Orofacial Sciences. 2006;1:9–14.


Wellcome Trust Grant Number 110110