ETHYL ACETATE LEAF FRACTION OF TAMARINDUS INDICA AND ALTERED BRAIN METALS FOLLOWING PRENATAL ALUMINUM CHLORIDE EXPOSURE IN WISTAR RATS

Back ground: The continuous and worrisome exposure to Aluminum and ability effectively mimic various metals in their respective biological functions to trigger biochemical abnormalities calls for serious concerns. Recent, attention is been diverted to various plant considering the different phytochemicals the contain. The present study investigated phytochemical compositions of ethyl acetate leaf fraction of Tamarindus indica (EATI) and its effect in altered brain metal concentration following prenatal aluminium chloride (AlCl₂) exposure in wistar rats.

Methodology: Preliminary phytochemical and GC/MS was carried out following extraction and fractionation of Tamarindus indica leaf. Pregnant timed rats were divided into 5 groups of 4 each. Group 1 received distilled water, Groups 2, 3, 4 and 5 were exposed to 100mg/kg of AlCl₃, in addition Groups 3 and 4 receiving 400mg/kg and 800mg/kg of EATI respectively and Group 5 receiving 30mg/kg of Vitamin E. All administration was done orally, from prenatal day 7 to 21. Body weights and brain metal (copper, zinc, iron and calcium) quantification was done a digital weighing balance and atomic absorption spectrophotometer.

Result: The present spread sheets contains the data set for brain zinc, calcium, copper and iron concentration and GC/MS result