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Liver function tests and fibrosis scores in a rural population in Africa

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dataset
modified on 20.01.2020, 08:45
This is a dataset to support an analysis to estimate the prevalence and aetiology of liver disease in a rural population in Uganda.

The data were collected in 2011 from the Uganda General Population Cohort (GPC), based in Kyamulibwa, in the Kalungu district of South-Western Uganda, established in 1989 (partners: UK Medical Research Council, Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine).

We have assessed the prevalence of liver disease based on liver function tests (LFTs) and fibrosis scores, and estimated the burden of liver disease associated with alcohol, hepatitis b virus (HBV), HIV, and high or low body mass index.

The files included here are as follows:

1. Complete metadata underpinning the analysis, labelled 'GPC metadata table', provided as xls and csv files.

2. STROBE statement (STrengthening the Reporting of OBservational studies in Epidemiology)

3. A pdf document containing supplementary material (tables and figures), as follows:

Suppl Table 1: Origin, reference ranges and clinical significance of liver function tests (LFTs)

Suppl Table 2: Scores to estimate liver fibrosis, calculated from liver function tests

Suppl Table 3: Description of characteristics of study participants with liver function test (LFT) results from the Ugandan General Population Cohort (N=8,099)

Suppl Table 4: Median and inter-quartile range for each liver function test with the population divided by risk factors

Suppl Fig 1: Distribution of liver function tests in Uganda General Population Cohort.

Suppl Fig 2: Odds ratio for deranged ALT, AST, APRI, GPR and AST/ALT among participants grouped by sex and age.

Suppl Fig 3: Proportion of Uganda General Population cohort reporting alcohol consumption among individuals with and without AST/ALT ratio >2

Suppl Fig 4: Proportion of Uganda General Population Cohort with elevated GGT, according to AST/ALT ratio. (A) males, with upper limit of normal GGT=61 (B) females, with upper limit of normal GGT=36. P-values by Fisher’s Exact Test

Suppl Fig 5: Proportion of Uganda General Population Cohort with blood borne virus (BBV) infection, according to GPR score. P-value by Fisher’s Exact Test, showing significant enrichment of BBV infection among individuals with elevated GPR score >0.32.


Ethics approval for this study was provided by:
- the Science and Ethics committee of the UVRI (GC/127/12/11/06)
- the Ugandan National Council for Science and Technology (HS870)
- the East of England-Cambridge South (formerly Cambridgeshire 4) NHS Research Ethics Committee UK (11/H0303/5).
All participants provided written informed consent.

Funding

Wellcome Trust, 110110 to Philippa Matthews; UK Medical Research Council to the Uganda General Population Cohort

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