TimeTalk_CB_manuscript_code_data

TimeTalk[https://github.com/ChengLiLab/TimeTalk] is an R package to perform cell-cell communication studies by utilizing temporal information behind single-cell sequencing, which is suitable for development biology research. In brief, TimeTalk uses the temporal information unraveled by trajectory analysis and the Granger causal test to test the ligand-receptor pairs with causal relationships to master transcription factors during development. Therefore it can elucidate the potential causal relationship between ligand-receptor interaction and TF activity. 

This repository is the code and related data for the reproducibility of the TimeTalk manuscript.