Proteomic changes during human heat stress and heat acclimation

It is expected that humans will need to adapt behaviorally, but also physiologically to thrive in climate that will be characterized by more frequent heat extremes. Yet, the cellular and molecular responses involved in human heat stress and adaptation remain poorly understood. We conducted an untargeted, large-scale analysis of human plasma proteomics during acute heat stress and subsequent heat adaptation. We tested 2938 plasma proteins (Olink Explore 3072) of 10 healthy adults (4 females/6 males, 25 ± 3 years) before and during exposure to passive heat stress that increased core temperature by ~1.5°C, prior and at the end of a 7-day heat acclimation protocol.