neo-Clerodane Diterpenoids and Other Constituents of Salvia
filipes
Version 2 2016-10-24, 13:32
Version 1 2016-09-28, 17:24
Posted on 2016-09-28 - 00:00
A series of neo-clerodane-type
diterpenoids were
isolated from the aerial parts of Salvia filipes,
including the new compounds 4-epi-polystachyne A
(1), salvifilines A (3), C (7), and D (8), and salvifiline B, which was isolated
as the 15-O-methyl derivatives 4/5. In addition, the five known diterpenoids (2, 9–12), together with ursolic,
oleanolic, and betulinic acids, and the flavone eupatorin were also
isolated. The structures were determined by analysis of their spectroscopic
data, mainly 1D and 2D NMR. The structure of salvifiline D was confirmed
by X-ray analysis. The cytotoxic activities of the diterpenoids were
evaluated, but all were inactive against a panel of six human cancer
cell lines.
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Maldonado, Emma; Galicia, Leonel; Chávez, Ma. Isabel; Hernández-Ortega, Simón (2016). neo-Clerodane Diterpenoids and Other Constituents of Salvia
filipes. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.6b00605
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AUTHORS (4)
EM
Emma Maldonado
LG
Leonel Galicia
MC
Ma. Isabel Chávez
SH
Simón Hernández-Ortega