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N,N′‑Bisaryl Substituted Chiral Linker-Bridged Bis(N‑Heterocyclic Carbene) Palladium Complexes: Design, Synthesis, and Catalytic Properties

Posted on 2017-03-24 - 12:48
A series of novel N,N′-bisaryl bis­(NHC) (NHC = N-heterocyclic carbene) precursors 5ae, 12ad, and 13ac and their palladium complexes 14ae, 15ad, and 16a,b with (1R,2R)-cyclohexene and (1R,2R)-diphenylethylene linkers have been designed, synthesized in good yields, and fully characterized by NMR, HRMS, and elemental analysis. The X-ray single crystal analysis of 15a showed that these complexes adopted a slightly distorted square-planar geometry around the Pd­(II) center. These N,N′-bisaryl-bis­(NHC)-Pd complexes exhibit excellent catalytic activity in asymmetric aryl–aryl cross-coupling reactions of arylboronic acids and aryl halides. The axial chiral biaryl compounds could be achieved in high yields (up to 74%) and good enantioselectivities (up to 60% ee) within 24 h. The results show that for this kind of bis­(NHC) palladium catalysts the structure characteristics of the chiral linkers have decisive effect on the enantioselectivities of cross-coupling reactions.

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