Ultrasensitive Detection of Amyloid‑β Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles–Poly(3,4-ethylene dioxythiophene)–Poly(thiophene-3-acetic acid) Composite Electrode

Published on 2019-08-13T20:29:38Z (GMT) by
A highly sensitive electrochemical impedance sensor for amyloid beta oligomer (AβO) was fabricated using a cellular prion protein (PrP<sup>C</sup>) bioreceptor linked with poly­(thiophene-3-acetic acid) transducer. An additional thin layer of poly­(3,4-ethylene dioxythiophene) embedded with gold nanoparticles was employed to provide high electrical conductivity and a large surface area. The sensing performace was investigated in terms of sensitivity and detection range. The fabricated sensor exhibited extremely low detection limit at a subfemtomolar level with a wide detection range from 10<sup>–8</sup> to 10<sup>4</sup> nM and its utility was established in mice infected with Alzheimer’s disease (AD). The developed AβO sensor could be utilized for early diagnosis of AD.

Cite this collection

Qin, Jieling; Cho, Misuk; Lee, Youngkwan (2019): Ultrasensitive Detection of Amyloid‑β

Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles–Poly(3,4-ethylene

dioxythiophene)–Poly(thiophene-3-acetic acid) Composite Electrode. ACS Publications. Collection.