Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011
Posted on 2016-12-05 - 05:00
Abstract Background Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients. Methods Pooled data from 61 895 malignant melanoma patients diagnosed between 2002 and 2011 and documented in 28 German population-based and hospital-based clinical cancer registries were analysed using descriptive methods, joinpoint regression, logistic regression and relative survival. Results The number of annually documented cases increased by 53.2% between 2002 (N = 4 779) and 2011 (N = 7 320). There was a statistically significant continuous positive trend in the proportion of stage UICC I cases diagnosed between 2002 and 2011, compared to a negative trend for stage UICC II. No trends were found for stages UICC III and IV respectively. Age (OR 0.97, 95% CI 0.97–0.97), sex (OR 1.18, 95% CI 1.11–1.25), date of diagnosis (OR 1.05, 95% CI 1.04–1.06), ‘diagnosis during screening’ (OR 3.24, 95% CI 2.50–4.19) and place of residence (OR 1.23, 95% CI 1.16–1.30) had a statistically significant influence on the tumour stage at diagnosis. The overall 5-year relative survival for invasive cases was 83.4% (95% CI 82.8–83.9%). Conclusions No distinct changes in the distribution of malignant melanoma tumour stages among those aged 35 and older were seen that could be directly attributed to the introduction of skin cancer screening in 2008.
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Schoffer, Olaf; Schülein, Stefanie; Arand, Gerlinde; Arnholdt, Hans; Baaske, Dieter; Bargou, Ralf; et al. (2016). Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3602048.v1
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AUTHORS (58)
OS
Olaf Schoffer
SS
Stefanie Schülein
GA
Gerlinde Arand
HA
Hans Arnholdt
DB
Dieter Baaske
RB
Ralf Bargou
NB
Nikolaus Becker
MB
Matthias Beckmann
YB
Yves Bodack
BB
Beatrix Böhme
TB
Tayfun Bozkurt
RB
Regine Breitsprecher
AB
Andre Buchali
EB
Elke Burger
UB
Ulrike Burger
KD
Klaus Dommisch
GE
Gudrun Elsner
KF
Karin Fernschild
UF
Ulrike Flintzer
UF
Uwe Funke