The origins and genomic diversity of American Civil War Era smallpox vaccine strains
Posted on 2020-07-20 - 04:06
Abstract Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vaccination viruses within the poxviruses as a whole.
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Duggan, Ana T.; Klunk, Jennifer; Porter, Ashleigh F.; Dhody, Anna N.; Hicks, Robert; Smith, Geoffrey L.; et al. (2020). The origins and genomic diversity of American Civil War Era smallpox vaccine strains. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5067324.v1
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AUTHORS (22)
AD
Ana T. Duggan
JK
Jennifer Klunk
AP
Ashleigh F. Porter
AD
Anna N. Dhody
RH
Robert Hicks
GS
Geoffrey L. Smith
MH
Margaret Humphreys
AM
Andrea M. McCollum
WD
Whitni B. Davidson
KW
Kimberly Wilkins
YL
Yu Li
AB
Amanda Burke
HP
Hanna Polasky
LF
Lowell Flanders
DP
Debi Poinar
AR
Amogelang R. Raphenya
TL
Tammy T. Y. Lau
BA
Brian Alcock
AM
Andrew G. McArthur
GG
G. Brian Golding