The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda
Posted on 2018-04-27 - 05:00
Abstract Background The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs). Methods In 2014, two VDPVs type 2 were identified during routine surveillance of acute flaccid paralysis (AFP) cases. Consequently, a retrospective VDPV survey was conducted to ensure that there was no circulating VDPV in the country. All Sabin poliovirus isolates identified in Uganda 6Â months before and 6Â months after were re-screened; Sabin 1 and 3 polioviruses were re-screened for Sabin 2 and Sabin 2 polioviruses were re-screened for VDPVs type 2. The Poliovirus rRT-PCR ITD/VDPV 4.0 assay and sequencing were used respectively. Results The first two VDPVs type2 were identified in Eastern Uganda and the third was identified during the survey from South-western Uganda. These regions had low OPV coverage and poor AFP surveillance indicators. Conclusion The retrospective VDPV survey was a useful strategy to screen for VDPVs more exhaustively. Supplementary surveillance methods need to be encouraged.
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Nanteza, Mary; Bakamutumaho, Barnabas; Kisakye, Annet; Namuwulya, Prossy; Bukenya, Henry; Katushabe, Edson; et al. (2018). The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4082789.v1
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AUTHORS (10)
MN
Mary Nanteza
BB
Barnabas Bakamutumaho
AK
Annet Kisakye
PN
Prossy Namuwulya
HB
Henry Bukenya
EK
Edson Katushabe
JB
Josephine Bwogi
CB
Charles Byabamazima
RW
Raffaella Williams
NG
Nicksy Gumede