The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy
Posted on 2017-04-04 - 05:00
Abstract Background The Hippo signaling pathway is reported to be involved in angiogenesis, but the roles of the Hippo pathway in diabetic retinopathy have not been addressed. Fufang Xueshuantong Capsule has been used to treat diabetic retinopathy in China; however, the effect of Fufang Xueshuantong Capsule on the Hippo pathway has not been investigated. Methods In this study, diabetes was induced in Sprague-Dawley rats with intraperitoneal injection of streptozotocin. Twenty weeks later, Fufang Xueshuantong Capsule was administered for 12Â weeks. When the administration ended, the eyes were isolated for western blot and immunohistochemistry analyses. The levels of P- mammalian sterile 20-like (MST), large tumor suppressor homolog (Lats), P- yes-associated protein (YAP), transcriptional co-activator with PDZ binding motif (TAZ) and TEA domain family members (TEAD) were measured. Results Diabetic rats had a decreased P-MST level in the inner plexiform layer and reduced expression of P-YAP in the photoreceptor layers of their eyes. In addition, diabetic rats displayed remarkable increases in Lats, TAZ and TEAD in their retinas. Furthermore, Fufang Xueshuantong Capsule restored the changes in the Hippo pathway. Conclusions The Hippo signaling pathway is important for the progression of diabetic retinopathy and will hopefully be a targeted therapeutic approach for the prevention of diabetic retinopathy.
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Hao, Gai-mei; Lv, Tian-tian; Wu, Yan; Wang, Hong-liang; Xing, Wei; Wang, Yong; et al. (2017). The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3733108.v1
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AUTHORS (11)
GH
Gai-mei Hao
TL
Tian-tian Lv
YW
Yan Wu
HW
Hong-liang Wang
WX
Wei Xing
YW
Yong Wang
CL
Chun Li
ZZ
Zi-jian Zhang
ZW
Zheng-lin Wang
WW
Wei Wang
JH
Jing Han