Targeted
Theranostics for Tuberculosis: A Rifampicin-Loaded
Aggregation-Induced Emission Carrier for Granulomas Tracking and Anti-Infection
Posted on 2020-06-15 - 14:39
Tuberculosis
(TB) causes a global burden with its high rates of
infection and death, especially the irrepressible threats of latent
infection and drug resistance. Therefore, it is important to construct
efficient theranostics for the prevention and control of TB. Herein,
we created a targeted theranostic strategy for TB with a rifampicin-loaded
aggregation-induced emission (AIE) carrier and performed testing in
laboratory animals. The AIE carrier was constructed to localize in
the granulomas and emit fluorescent signals at the early stage of
infection, enabling the early diagnosis of TB. Subsequently, reactive
oxygen species (ROS) were generated to eradicate infection, and the
loaded rifampicin (RIF) was released for the synergistic treatment
of persistent bacteria. Furthermore, targeted TB therapy was performed
with the light-controlled release of ROS and accurate delivery of
RIF, which realizes an anti-infection effect, providing an especially
important treatment for drug-resistant TB. Thus, targeted theranostics
for TB in laboratory animals possess the potential to become granulomas-tracking
and anti-infection strategies for the diagnosis and treatment of TB.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Liao, Yuhui; Li, Bin; Zhao, Zheng; Fu, Yu; Tan, Qingqin; Li, Xingyu; et al. (2020). Targeted
Theranostics for Tuberculosis: A Rifampicin-Loaded
Aggregation-Induced Emission Carrier for Granulomas Tracking and Anti-Infection. ACS Publications. Collection. https://doi.org/10.1021/acsnano.0c00586
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
AUTHORS (11)
YL
Yuhui Liao
BL
Bin Li
ZZ
Zheng Zhao
YF
Yu Fu
QT
Qingqin Tan
XL
Xingyu Li
WW
Wei Wang
JY
Jialing Yin
HS
Hong Shan
BT
Ben Zhong Tang
XH
Xi Huang