Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective Protonation of (<i>E</i>)‑α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated Esters

Published on 2018-09-14T12:51:13Z (GMT) by
A tandem Cu­(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective protonation of (<i>E</i>)-α<b>-</b>trialkylsilyl-β-alkyl­(aryl)-α,β-unsaturated esters afforded the saturated products with d.r. values of >20:1 favoring the anti-diastereomer in modest to excellent isolated yields.

Cite this collection

Johnson, David

A.; Jennings, Michael P. (2018): Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective

Protonation of (E)‑α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated

Esters. ACS Publications. Collection.