Synthesis of quinoline based [1,2,4]-dithiazolidines through sulfur-sulfur bond formation and their evaluation as anti-inflammatory and antibacterial agents

A series of [1,2,4]-dithiazolidines carrying the quinoline moiety has been synthesized. 2-Chloroquinolin-3-carbaldehyde reacted with various 4-arylthiosemicarbazides to form the corresponding 1-[(2-chloroquinolin-3-yl)methylene]-4-arylthiosemicarbazides. The synthesis of 3,5-(diarylimino)-4[(2-chloroquinolin-3-yl)methyleneamino]-[1,2,4]-dithiazolidines was achieved by the interaction of 1-[(2-chloroquinolin-3-yl)methylene]-4-arylthiosemicarbazides with N-aryl-S-chloroisothiocarbamoyl chlorides through S–S and C–N bond formations. The structures of newly synthesized compounds were confirmed on the basis of IR, ¹H & ¹³C NMR and Mass spectral data. The title compounds were screened for their anti-inflammatory and antibacterial activities.