Synthesis of Well-Defined Bifunctional Newkome-Type
Dendrimers
Posted on 2017-06-23 - 18:35
Four bifunctional
Newkome-type 1 → 3 branched polyamide-based
dendrimers with different spatial arrangements of azido and alkenyl
termini were synthesized. The dendrimer synthesis started with three
building blocks containing two different ester protecting groups that
can be deprotected in an orthogonal fashion. This orthogonal deprotection
strategy allowed for the synthesis of three bifunctional dendrimers
in a convergent fashion and one dendrimer via a divergent synthetic
route. These four dendrimers have different spatial arrangements of
termini capable of undergoing further functionalization using 1,3-dipolar
cycloaddition and thiol–ene type click chemistries. The precise
placement of the functional moieties along the dendrimer surface allows
for dendrimer functionalization with a known ratio of cargo and exact
placement on the periphery.
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Kaufman, Elizabeth
A.; Tarallo, Rossella; Elacqua, Elizabeth; Carberry, Tom P.; Weck, Marcus (2017). Synthesis of Well-Defined Bifunctional Newkome-Type
Dendrimers. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.7b01035
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AUTHORS (5)
EK
Elizabeth
A. Kaufman
RT
Rossella Tarallo
EE
Elizabeth Elacqua
TC
Tom P. Carberry
MW
Marcus Weck