Synthesis and Biological Evaluation of Hippolachnin
A Analogues
Posted on 2018-06-18 - 21:21
The marine polyketide
hippolachnin A (1) has attracted
considerable attention from synthetic chemists due to both its intricate
core structure and attractive biological activity against virulent
fungi. Described herein are recent efforts to employ our recently
developed synthesis in structure–activity relationship studies
of 1. These studies have revealed that, in contrast to
initial reports, 1 and several structural analogues lack
activity against pathogenic fungi.
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Timmerman, Jacob C.; Wood, John L. (2018). Synthesis and Biological Evaluation of Hippolachnin
A Analogues. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b01381
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