Surfactant-Free
Preparation of Au@Resveratrol Hollow
Nanoparticles with Photothermal
Performance and Antioxidant Activity
Posted on 2017-01-18 - 17:51
Nanocomposites
based on hollow Au nanostructures have gained considerable
attention in theranostics applications because of their unique plasmonic
structures and attractive physicochemical properties. The exploration
of feasible and facile methods for constructing multifunctional nanocomposites
combined with bioactive molecules is greatly needed for the development
of multifunctional theranostics platforms. In this work, resveratrol,
a natural polyphenol with antioxidant activity and cancer-chemopreventive
propertyies is employed as the reducing agent cum coating agent for
the surfactant-free preparation of Au@resveratrol hollow NPs (Au@Res
HNPs). The as-prepared Au@Res HNPs were found to present good photothermal
performance and chemical inhibition for cancer therapy. In vitro experiments
indicated that the Au@Res HNPs can block cell cycles to inhibit cell
division and lead to cell apoptosis after 808-nm laser irradiation.
Because no toxic surfactants are introduced, the current protocol
avoids the tedious surfactant separation and surface modification
processes that are necessary for most theranostics materials.
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Wang, Wenjing; Tang, Qi; Yu, Tianrong; Li, Xing; Gao, Yang; Li, Jing; et al. (2017). Surfactant-Free
Preparation of Au@Resveratrol Hollow
Nanoparticles with Photothermal
Performance and Antioxidant Activity. ACS Publications. Collection. https://doi.org/10.1021/acsami.6b13911
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AUTHORS (12)
WW
Wenjing Wang
QT
Qi Tang
TY
Tianrong Yu
XL
Xing Li
YG
Yang Gao
JL
Jing Li
YL
Yi Liu
LR
Li Rong
ZW
Zhigang Wang
HS
Hongchen Sun
HZ
Hao Zhang
BY
Bai Yang
KEYWORDS
multifunctional nanocompositesPhotothermal Performancebioactive moleculessurfactant-free preparationantioxidant activitySurfactant-Free Preparationsurface modification processesagent cum coating agentphotothermal performancechemical inhibitionmultifunctional theranostics platformsHNPcell divisionNPcell cyclesplasmonic structuresphysicochemical propertiesAntioxidant Activity Nanocompositescell apoptosis808- nm laser irradiationtheranostics materialssurfactant separationtheranostics applicationscancer therapycancer-chemopreventive propertyies