Surface Preconditioning Influences the Antifouling
Capabilities of Zwitterionic and Nonionic Polymer Brushes
Posted on 2020-06-18 - 20:30
Polymer brushes not
only represent emerging surface platforms for
numerous bioanalytical and biological applications but also create
advanced surface-tethered systems to mimic real-life biological processes.
In particular, zwitterionic and nonionic polymer brushes have been
intensively studied because of their extraordinary resistance to nonspecific
adsorption of biomolecules (antifouling characteristics) as well as
the ability to be functionalized with bioactive molecules. However,
the relation between antifouling behavior in real-world biological
media and structural changes of polymer brushes induced by surface
preconditioning in different environments remains unexplored. In this
work, we use multiple methods to study the structural properties of
numerous brushes under variable ionic concentrations and determine
the impact of these changes on resistance to fouling from undiluted
blood plasma. We describe different mechanisms of swelling, depending
on both the polymer brush coating properties and the environmental
conditions that affect changes in both hydration levels and thickness.
Using both fluorescent and surface plasmon resonance methods, we found
that the antifouling behavior of these brushes is strongly dependent
on the aforementioned structural changes. Moreover, preconditioning
of the brush coatings (incubation at a variable salt concentration
or drying) prior to biomolecule interaction may significantly improve
the antifouling performance. These results suggest a new simple approach
to improve the antifouling behavior of polymer brushes. In addition,
the results herein enhance the understanding for improved design of
antifouling and bioresponsive brushes employed in biosensor and biomimetic
applications.
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3 Biotech
3D Printing in Medicine
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3D-Printed Materials and Systems
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AAPG Bulletin
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Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
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Academic Medicine
Academic Pediatrics
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Víšová, Ivana; Vrabcová, Markéta; Forinová, Michala; Zhigunová, Yulia; Mironov, Vasilii; Houska, Milan; et al. (2020). Surface Preconditioning Influences the Antifouling
Capabilities of Zwitterionic and Nonionic Polymer Brushes. ACS Publications. Collection. https://doi.org/10.1021/acs.langmuir.0c00996
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AUTHORS (12)
IV
Ivana Víšová
MV
Markéta Vrabcová
MF
Michala Forinová
YZ
Yulia Zhigunová
VM
Vasilii Mironov
MH
Milan Houska
EB
Eva Bittrich
KE
Klaus-Jochen Eichhorn
HH
Hisham Hashim
PS
Petr Schovánek
AD
Alexandr Dejneka
HV
Hana Vaisocherová-Lísalová