Supplementary material from "Using phosphine ligands with a biological role to modulate its reactivity in novel platinum complexes"

Three platinum complexes with cis and trans configuration: cis-[Pt(TCEP)₂Cl₂], cis-[Pt(tmTCEP)₂Cl₂] and trans-[Pt(TCEP)₂Cl₂], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)₂Cl₂] and cis-[Pt(tmTCEP)₂Cl₂]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds has also been studied. The interaction of the complexes with biological models such as DNA (pBR222 and CT-DNA) and proteins (lysozyme and RNase) is evaluated.