Supplementary material from "Using phosphine ligands with a biological role to modulate its reactivity in novel platinum complexes"
Posted on 2018-02-01 - 11:42
Three platinum complexes with cis and trans configuration: cis-[Pt(TCEP)2Cl2], cis-[Pt(tmTCEP)2Cl2] and trans-[Pt(TCEP)2Cl2], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)2Cl2] and cis-[Pt(tmTCEP)2Cl2]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds has also been studied. The interaction of the complexes with biological models such as DNA (pBR222 and CT-DNA) and proteins (lysozyme and RNase) is evaluated.
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Echeverri, Marcelo; Alvarez-Valdés, Amparo; Navas, Francisco; Perles, Josefina; Sánchez-Pérez, Isabel; Quiroga, A. G. (2018). Supplementary material from "Using phosphine ligands with a biological role to modulate its reactivity in novel platinum complexes". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.3992886.v1