Supplementary material from "TSNAD: an integrated software for cancer somatic mutation and tumour-specific neoantigen detection"
Posted on 2017-03-21 - 10:05
Tumour antigens have attracted much attention because of their importance to cancer diagnosis, prognosis and targeted therapy. With the development of cancer genomics, the identification of tumour-specific neoantigens became possible, which is a crucial step for cancer immunotherapy. In this study, we developed software called the tumour-specific neoantigen detector for detecting cancer somatic mutations following the best practices of the genome analysis toolkit and predicting potential tumour-specific neoantigens, which could be either extracellular mutations of membrane proteins or mutated peptides presented by class I major histocompatibility complex molecules. This pipeline was beneficial to the biologist with little programmatic background. We also applied the software to the somatic mutations from the International Cancer Genome Consortium database to predict numerous potential tumour-specific neoantigens. This software is freely available from https://github.com/jiujiezz/tsnad.
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Zhou, Zhan; Lyu, Xingzheng; Wu, Jingcheng; Yang, Xiaoyue; Wu, Shanshan; Zhou, Jie; et al. (2017). Supplementary material from "TSNAD: an integrated software for cancer somatic mutation and tumour-specific neoantigen detection". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.3721813.v1
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AUTHORS (9)
ZZ
Zhan Zhou
XL
Xingzheng Lyu
JW
Jingcheng Wu
XY
Xiaoyue Yang
SW
Shanshan Wu
JZ
Jie Zhou
XG
Xun Gu
ZS
Zhixi Su
SC
Shuqing Chen