Supplementary material from "Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin"
Posted on 2018-10-04 - 10:46
Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g−1, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug-loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.
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Cardoso, Beatriz D.; Rio, Irina S. R.; Rodrigues, Ana Rita O.; Fernandes, Francisca C. T.; Almeida, B. G.; Pires, A.; et al. (2018). Supplementary material from "Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.4254130.v1
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AUTHORS (10)
BC
Beatriz D. Cardoso
IR
Irina S. R. Rio
AR
Ana Rita O. Rodrigues
FF
Francisca C. T. Fernandes
BA
B. G. Almeida
AP
A. Pires
AP
A. M. Pereira
JA
J. P. Araújo
EM
Elisabete M. S. Castanheira
PJ
Paulo J. G. Coutinho