Supplementary material from "Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents"
Version 2 2018-03-29, 11:17
Version 1 2018-03-24, 12:06
Posted on 2018-03-29 - 11:17
A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibits significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56–12.5 μg ml−1. Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 μg ml−1. Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor.
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Nalla, Viswanadh; Shaikh, Aslam; Bapat, Sanket; Vyas, Renu; Karthikeyan, M.; Yogeeswari, P.; et al. (2018). Supplementary material from "Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.4041434.v2
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AUTHORS (8)
VN
Viswanadh Nalla
AS
Aslam Shaikh
SB
Sanket Bapat
RV
Renu Vyas
MK
M. Karthikeyan
PY
P. Yogeeswari
DS
D. Sriram
MM
M. Muthukrishnan