Structural
Design and Synthesis of Bimodal PNA That Simultaneously Binds Two
Complementary DNAs To Form Fused Double Duplexes

Ganesh, Krishna N.

Structural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexes

Posted on 2020-06-18 - 13:04

Bimodal PNAs are new PNA constructs designed to bind two different cDNA sequences synchronously to form double duplexes. They are synthesized on solid phase using sequential coupling and click reaction to introduce a second base in each monomer at C_α via alkyltriazole linker. The ternary bimodal PNA:DNA complexes show stability higher than that of individual duplexes. Bimodal PNAs are appropriate to create higher-order fused nucleic acid assemblies.

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Gupta, Manoj Kumar; Madhanagopal, Bharath Raj; Datta, Dhrubajyoti; Ganesh, Krishna N. (2020). Structural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexes. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01950

https://doi.org/10.1021/acs.orglett.0c01950

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