Sperm-Hybrid
Micromotor for Targeted Drug Delivery
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Posted on 2017-12-21 - 11:14
A sperm-driven
micromotor is presented as a targeted drug delivery
system, which is appealing to potentially treat diseases in the female
reproductive tract. This system is demonstrated to be an efficient
drug delivery vehicle by first loading a motile sperm cell with an
anticancer drug (doxorubicin hydrochloride), guiding it magnetically,
to an in vitro cultured tumor spheroid, and finally
freeing the sperm cell to deliver the drug locally. The sperm release
mechanism is designed to liberate the sperm when the biohybrid micromotor
hits the tumor walls, allowing it to swim into the tumor and
deliver the drug through the sperm–cancer cell membrane
fusion. In our experiments, the sperm cells exhibited a high drug
encapsulation capability and drug carrying stability, conveniently
minimizing toxic side effects and unwanted drug accumulation
in healthy tissues. Overall, sperm cells are excellent candidates
to operate in physiological environments, as they neither express
pathogenic proteins nor proliferate to form undesirable colonies,
unlike other cells or microorganisms. This sperm-hybrid micromotor
is a biocompatible platform with potential application in gynecological
healthcare, treating or detecting cancer or other diseases in the
female reproductive system.
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Xu, Haifeng; Medina-Sánchez, Mariana; Magdanz, Veronika; Schwarz, Lukas; Hebenstreit, Franziska; Schmidt, Oliver G. (2017). Sperm-Hybrid
Micromotor for Targeted Drug Delivery. ACS Publications. Collection. https://doi.org/10.1021/acsnano.7b06398