Solid Lipid Nanoparticles Enhanced the Neuroprotective
Role of Curcumin against Epilepsy through Activation of Bcl‑2
Family and P38 MAPK Pathways
Posted on 2020-06-11 - 21:29
Oxidative
stress of neurons caused by a series of complex neuropathological
processes will induce certain neurodegenerative disorders including
epilepsy. Curcumin (Cur) is an effective natural antioxidant compound;
however, the poor bioavailability obstructs its neural protective
applications. In this study, Cur is encapsulated in solid lipid nanoparticles
(SLNs) for better neuroprotective efficacy. In vitro study certified
that Cur-SLNs functioned obviously better against neuronal apoptosis
than Cur, by significantly decreasing the level of free radical and
reversing mitochondrial function through the activation of the Bcl-2
family. In vivo experiments showed that SLNs transported Cur through
the blood–brain barrier (BBB). The behavioral performance of
epileptic mice was improved by Cur-SLNs, with more NeuN but less TUNEL
positive cells observed in hippocampus. The in vivo mechanism was
also explored. Cur-SLNs reduced neuronal apoptosis through Bcl2 family
and P38 MAPK pathways. Overall, Cur-SLNs have better protective effects
toward oxidative stress in neurons than free Cur both in vitro and
in vivo, which suggests they may be a promising agent against neurodegenerative
disorders including epilepsy.
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Huang, Ruiqi; Zhu, Yanjing; Lin, Lijuan; Song, Simin; Cheng, Liming; Zhu, Rongrong (2020). Solid Lipid Nanoparticles Enhanced the Neuroprotective
Role of Curcumin against Epilepsy through Activation of Bcl‑2
Family and P38 MAPK Pathways. ACS Publications. Collection. https://doi.org/10.1021/acschemneuro.0c00242
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AUTHORS (6)
RH
Ruiqi Huang
YZ
Yanjing Zhu
LL
Lijuan Lin
SS
Simin Song
LC
Liming Cheng
RZ
Rongrong Zhu